FORMULIERUNGEN

Manufacturing Process
Phase A: Mix phase A and stir until everything is completely dissolved.
Phase B: Add phase B to phase A and stir until dispersed.
Phase C: Slowly add phase C to phase A+B and stir until complete dissolution.
Phase D: Mix all ingredients of phase D and heat phase A+B+C and D separately to 80 °C.
Add phase D slowly to phase A+B+C while stirring.
Phase E: Dissolve Cosphaderm® Panthenol natural in water and add to the finished formulation (below 40 °C).
Adjust the pH to 5.5 ± 0.05.

Specification
Appearance: Shiny, fluid emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Prepare phase A and stir until complete dissolution.
Phase B: Prepare phase B and heat to 50 °C until everything is melted. Let the mixture cool down to room temperature.
Add phase B to phase A and homogenise.
Adjust the pH to 5.5 ± 0.05.

Specification
Appearance: White, viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A and stir until complete dissolution.
Adjust the pH value to 5.5 ± 0.05.
Phase B: Prepare phase B in a separate beaker.
Add phase B to phase A without stirring and pour mixture into spray flask.

Specification
Appearance: Liquid two-phase system with oil phase on top of transparent water phase
pH: 5.5 ± 0.05
Stability: Stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A and stir until everything is dissolved.
Phase B: Slowly add phase B to phase A under stirring. Stir until complete dissolution.
Adjust pH to 5.5 ± 0.05 and heat phase A and B to 70 °C.
Phase C: Combine all ingredients and heat phase C to 70 °C. Add then phase C to phase A and B under strong stirring and homogenise the formulation.
Adjust pH to 5.2 ± 0.05.

Specification
Appearance: Slightly yellowish gel cream
pH: 5.2 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A and stir until everything is dissolved.
Phase B: Combine all ingredients of phase B.
Add phase B into phase A and homogenise until everything is dissolved.
Adjust the pH to 6.5 ± 0.05.

Specification
Appearance: White viscous lotion
pH: 6.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Combine all ingredients of phase B.
Heat both phases separately to 70-75 °C and add phase B to A while homogenising.
Phase C: Dissolve Cosphaderm® Panthenol natural in water and add phase C below 40 °C.
Adjust the pH to 5.5 ± 0.05.

SPECIFICATION
Appearance: Translucent high viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A and stir until completely dissolved.
Phase B: Prepare phase B and separately heat phase A and phase B to 80 °C. Add phase B to phase A while stirring.
Phase C+D: Add phase C and D below 40 °C. Homogenise.
Adjust pH to 5.5 ± 0.05.

Specification
Appearance: Slightly yellowish, viscous cream
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Mix all ingredients of phase A under slow stirring.
Phase B: Mix all ingredients of phase B until everything is completely dissolved and add B to phase A.
Adjust the pH of phase A+B to 5.5 ± 0.05.
Phase C: Mix all ingredients of phase C and add the mixture to phase A+B without stirring.

Specification
Appearance: Two-phase system with coloured oil phase on top of transparent water phase
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven