FORMULATIONS

Phase A: Combine all ingredients of phase A and stir until everything is dissolved.
Phase B: Combine all ingredients of phase B and add to phase A under stirring. Stir until everything is dissolved.
Phase C: Add phase C.
Adjust the pH to 5.5 ± 0.05.

Appearance: Transparent, viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Dissolve Phase A at 40°C.
Phase B: Combine all ingredients of phase B separately and add to phase A under stirring.
Adjust pH to 5.5 ± 0.05 if necessary.

Appearance: Transparent, low viscous serum
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again.
Phase B: Combine Glycerin, Cosphaderm® X 34 and Cosphaderm® Sodium Hyaluronate high and stir until the powder is wetted. Then add it to phase A.
Phase C: Add phase C under stirring.
Adjust the pH to 4.0 ± 0.05.

Appearance: Transparent, semi-viscous gel
pH: 4.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Disperse the thickeners in glycerol and Cosphaderm® Propanediol natural.
Phase B: Add demin. water and stir until everything is dissolved.
Phase C: Add phase C to A/B.
Adjust the pH to 5.5 ± 0.05.

Appearance: Translucent, viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A.
Phase B: Combine all ingredients of phase B separately and add to phase A under stirring.
Phase C: Add phase C to A/B and stir until everything is completely dissolved.
Adjust pH to 5.5 ± 0.05.

Appearance: Transparent, low viscous serum
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is dissolved.
Phase B: Premix all ingredients of phase B and add to phase A while stirring.
Phase C: Combine the ingredients of phase C and add them to the formulation. Stir until everything is homogeneous.
Adjust pH to 5.5 ± 0.05.

Appearance: Clear, transparent, low viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Add phase B to phase A.
Phase C: Add phase C and stir until everything is completely dissolved.
Adjust pH to 6.5 ± 0.05 if necessary.

Appearance: Transparent, low viscous serum
pH: 6.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Combine all ingredients of phase B.
Heat both phases separately to 70-75 °C and add phase B to A while stirring. Then homogenise the formulation.
Phase C: Dissolve Cosphaderm® Magnolia Extract 98 in Cosphaderm® Dicapo natural.
Add phase C and phase D to phase A+B after cooling to 40 °C while stirring. Adjust the pH to 5.5 ± 0.05.

Appearance: Light beige, shiny, fluid emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 75 °C.
Phase B: Combine all ingredients and heat to 75 °C. Add then phase B to phase A under strong stirring and homogenise.
Phase C: Add phase C to the formulation and stir.
Adjust the pH to 5.5 ± 0.05.

Appearance: White, fluid emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 70-75 °C.
Phase B: Combine all ingredients of phase B and heat to 75°C. Phase C is added to the oil phase just before emulsion is formed.
Add phase B+C to the water phase while stirring. Homogenise at 40°C.
Adjust the pH to 5.5 ± 0.05.

Appearance: White, viscous cream
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A.
Phase B: Prepare phase B and slowly add to phase A under stirring. Continue stirring until everything is completely dissolved.
Adjust pH to 5.5 ± 0.05.

Appearance: Transparent, low viscous serum
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Prepare phase A.
Phase B: Pre-disperse phase B and add to the water phase while stirring. Stir until everything is completely dissolved.
Adjust the pH to 5.5 – 6.0 ± 0.05.
Heat the mixture to 80-90°C and keep this temperature for 2 – 3 minutes.
Quickly pour the hot mixture into moulds and let it cool down.

Appearance: Transparent or coloured, elastic jelly patch
pH: 5.5 – 6.0 ± 0.05
Stability: Stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Combine all ingredients of phase A and heat to 80-85 °C.
When everything has melted, take off heat and fill into packaging.

Appearance: Solid, yellowish balm
Stability: Stable for 3 months at room temperature and 40 °C
Microbiological stability: proven (Water activity value less than 0.75)

Phase A: Combine all ingredients of phase A and raise the pH to 11 under stirring to dissolve cinnamic acid. When everything is dissolved, lower the pH back to 6 again.
Add phase B to A and stir until everything is dissolved. Heat phase A/B to 75 °C.
Phase C: Combine all ingredients and heat to 80 °C. Add then phase C to phase A/B under strong stirring and homogenise.
Adjust the pH to 5.5 ± 0.05.

Appearance: White viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A.
Phase B: Prepare phase B and slowly add to phase A under stirring. Continue stirring until everything is
completely dissolved.
Phase C: Add phase C and stir until everything is homogeneous.
Adjust pH value to 5.50 ± 0.05.

Appearance: Clear, red, low viscous solution
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature
and 40 °C
Microbiological stability: proven