FORMULATIONS

Phase A: Combine all ingredients of phase A and raise the pH to 11 to dissolve cinnamic acid. When everything is dissolved, lower the pH back to 6 again.
Phase B: Add all ingredients of phase B to phase A and stir until a slightly viscous gel is formed.
Adjust pH to 5.5 ± 0.05.

Appearance: Yellowish, transparent, slightly viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A.
Phase B: Combine all ingredients of phase B separately and add to phase A under stirring.
Phase C: Add phase C to A/B and stir until everything is completely dissolved.
Adjust pH to 5.5 ± 0.05.

Appearance: Transparent, low viscous serum
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Add phase B to phase A under stirring.
Adjust the pH to 6.0 ± 0.05 to thicken the formulation.

Appearance: Transparent, clear, viscous gel
pH: 6.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A.
Phase B: Prepare phase B and slowly add to phase A under stirring. Continue stirring until everything is completely dissolved.
Adjust pH to 5.5 ± 0.05.

Appearance: Transparent, clear liquid
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Mix phase A and stir until everything is completely dissolved.
Phase B: Add phase B to phase A and stir until dispersed.
Phase C: Slowly add phase C to phase A+B and stir until complete dissolution.
Phase D: Mix all ingredients of phase D and heat phase A+B+C and D separately to 80 °C.
Add phase D slowly to phase A+B+C while stirring.
Phase E: Add phase E to the finished formulation (below 40 °C).
Adjust the pH to 5.5 ± 0.05.

Appearance: Shiny, fluid emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A.
Phase B: Prepare phase B and slowly add to phase A under stirring. Continue stirring until everything is completely dissolved.
Adjust pH to 5.5 ± 0.05.

Appearance: Transparent, low viscous serum
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until complete dissolution.
Adjust the pH value to 5.5 ± 0.05.
Phase B: Prepare phase B in a separate beaker.
Add phase B to phase A without stirring and pour mixture into spray flask.

Appearance: Liquid two-phase system with oil phase on top of transparent water phase
pH: 5.5 ± 0.05
Stability: Stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 70-75 °C.
Phase B: Combine all ingredients and heat to 75 °C. Add then phase B to phase A under strong stirring and homogenise.
Phase C: Add phase C below 40 °C.
Adjust the pH to 5.5 ± 0.05.

Appearance: White viscous fluid
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine the ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again.
Phase B: Add all ingredients from phase B one after another.
Adjust the pH to 4.0 ± 0.05.

Appearance: Transparent, low viscous solution
pH: 4.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Slowly add phase B to A while stirring.
Phase C: Mix all ingredients of phase C and add to phase A+B while stirring.
Adjust the pH to 5.0 ± 0.05.

Appearance: Transparent, low viscous serum
pH: 5.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is dissolved.
Phase B: Prepare all ingredients of phase B.
Afterwards combine phase A and B while stirring slowly until a homogeneous gel is formed.
Adjust pH to 5.5 ± 0.05.

Appearance: Yellowish, slightly turbid, viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A.
Phase B: Add phase B to phase A while stirring and stir until everything is completely dissolved.
Phase C: Prepare phase C and add to phase A+B under slow stirring to prevent foaming.
Adjust pH to 5.5 ± 0.05.

Appearance: Transparent, viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A.
Phase B: Add phase B to phase A while stirring and stir until everything is completely dissolved.
Phase C: Prepare phase C and add to phase A+B under slow stirring to prevent foaming.
Adjust pH to 5.5 ± 0.05.

Appearance: Transparent, viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is dissolved.
Phase B: Add phase B to phase A under stirring.
Phase C: Combine all ingredients of phase C separately. Add then phase C to phase A and B under stirring.
Adjust pH to 5.5 ± 0.05.

Appearance: Transparent liquid solution
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is dissolved. Heat to 65 °C.
Phase B: Prepare all ingredients of phase B and heat to 65 °C.
Add phase B to phase A under stirring. Homogenise.
Adjust the pH to 5.5 ± 0.05 if necessary.

Appearance: White viscous gel cream
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Add phase B to A carefully to avoid foaming.
Adjust the pH to 5.5 ± 0.05.
Phase C: Add phase C to the final formulation while stirring.

Appearance: Transparent gel with small peeling beads
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Combine all ingredients of phase B.
Heat both phases separately to 70-75 °C and add phase B to A while homogenising.
Phase C: Add phase C below 40 °C.
Adjust the pH to 5.5 ± 0.05.

Appearance: Translucent high viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 70-75 °C.
Phase B: Combine all ingredients and heat to 75 °C. Add then phase B to phase A under strong stirring and homogenise.
Phase C: Dissolve the menthol in Cosphaderm® Hexiol natural and add below 40°C.
Phase D: Add phase D below 40 °C.
Adjust the pH to 5.5 ± 0.05.

Appearance: White viscous lotion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Adjust the pH to 5.5 ± 0.05.
Phase B: Combine all ingredients of phase B.
Heat phase B to 80 °C and slowly add phase A to B while homogenising.

Appearance: White low viscous lotion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven