FORMULIERUNGEN

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 75 °C.
Phase B: Combine all ingredients and heat to 75 °C. Add then phase B to phase A under strong stirring and homogenise.
Phase C: Add phase C to the formulation and stir.
Adjust the pH to 5.5 ± 0.05.

Appearance: White, high viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 75 °C.
Phase B: Combine all ingredients and heat to 75 °C. Add then phase B to phase A under strong stirring and homogenise.
Phase C: Add phase C to the formulation and stir.
Adjust the pH to 5.5 ± 0.05.

Appearance: Yellowish green, high viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and raise the pH to 11 to dissolve cinnamic acid. When everything is dissolved, lower the pH back to 6 again.
Phase B: Add all ingredients of phase B to phase A and stir until a slightly viscous gel is formed.
Adjust pH to 5.5 ± 0.05.

Appearance: Yellowish, transparent, slightly viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is dissolved.
Phase B: Premix all ingredients of phase B and add to phase A while stirring.
Phase C: Combine the ingredients of phase C and add them to the formulation. Stir until everything is homogeneous.
Adjust pH to 5.5 ± 0.05.

Appearance: Clear, transparent, low viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A.
Phase B: Prepare phase B and slowly add to phase A under stirring. Continue stirring until everything is completely dissolved.
Adjust pH to 5.5 ± 0.05.

Appearance: Transparent, clear liquid
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 75 °C.
Phase B: Combine all ingredients and heat to 75 °C. Add then phase B to phase A under strong stirring and homogenise.
Phase C: Add phase C to the formulation and stir.
Adjust the pH to 5.5 ± 0.05.

Appearance: White, high viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Mix phase A and stir until everything is completely dissolved.
Phase B: Add phase B to phase A and stir until dispersed.
Phase C: Slowly add phase C to phase A+B and stir until complete dissolution.
Phase D: Mix all ingredients of phase D and heat phase A+B+C and D separately to 80 °C.
Add phase D slowly to phase A+B+C while stirring.
Phase E: Add phase E to the finished formulation (below 40 °C).
Adjust the pH to 5.5 ± 0.05.

Appearance: Shiny, fluid emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Prepare phase A and stir until complete dissolution.
Phase B: Prepare phase B and heat to 50 °C until everything is melted. Let the mixture cool down to room temperature.
Add phase B to phase A and homogenise.
Adjust the pH to 5.5 ± 0.05.

Appearance: White, viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients.
Phase B: Prepare phase B and slowly add to phase A under stirring. Continue stirring until everything is completely dissolved.
Adjust pH to 6.5 ± 0.05 if necessary.

Appearance: Translucent, low viscous serum
pH: 6.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 70-75 °C.
Phase B: Combine all ingredients and heat to 75 °C. Add then phase B to phase A under strong stirring and homogenise.
Phase C: Add phase C below 40 °C.
Adjust the pH to 5.5 ± 0.05.

Appearance: White viscous fluid
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine the ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again.
Phase B: Add all ingredients from phase B one after another.
Adjust the pH to 4.0 ± 0.05.

Appearance: Transparent, low viscous solution
pH: 4.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is dissolved.
Phase B: Add phase B to phase A under stirring.
Phase C: Combine all ingredients of phase C separately. Add then phase C to phase A and B under stirring.
Adjust pH to 5.5 ± 0.05.

Appearance: Transparent liquid solution
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until Cosphaderm® X 34 and Cosphaderm® Sodium Hyaluronate are dispersed.
Phase B: Add phase B to phase A.
Phase C: Add phase C to phase A+B under stirring.
Adjust the pH to 5.5 ± 0.05.

Appearance: Transparent, clear gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is dissolved.
Phase B: Combine all ingredients of phase B.
Add phase B into phase A and homogenise until everything is dissolved.
Adjust the pH to 6.5 ± 0.05.

Appearance: White viscous lotion
pH: 6.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 70-75 °C.
Phase B: Combine all ingredients and heat to 75 °C. Add then phase B to phase A under strong stirring and homogenise.
Phase C: Dissolve the menthol in Cosphaderm® Hexiol natural and add below 40°C.
Phase D: Add phase D below 40 °C.
Adjust the pH to 5.5 ± 0.05.

Appearance: White viscous lotion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven