FORMULATIONS

Manufacturing Process
Phase A: Combine all ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again.
Phase B: Combine Glycerin, Cosphaderm® X 34 and Cosphaderm® Sodium Hyaluronate high and stir until the powder is wetted. Then add it to phase A.
Phase C: Add phase C under stirring.
Adjust the pH to 4.0 ± 0.05.

Specification
Appearance: Transparent, semi-viscous gel
pH: 4.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Combine all ingredients of phase B separately and add to phase A under stirring.
Adjust pH to 5.5 ± 0.05 if necessary.

SPECIFICATION
Appearance: Transparent, low viscous serum
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural
completely.
Phase B: Add phase B and lower the pH to 4.0 ± 0.05.

Specification
Appearance: Clear, liquid solution
pH: 4.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Combine all ingredients of phase B.
Heat both phases separately to 70-75 °C and add phase B to A while stirring.
Then homogenise the formulation.
Phase C: Dissolve Cosphaderm® Magnolia Extract 98 in Cosphaderm® Dicapo natural.
Add phase C and phase D to phase A+B after cooling to 40 °C while stirring.
Adjust the pH to 5.5 ± 0.05.

SPECIFICATION
Appearance: Light beige, shiny, fluid emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A under stirring until Cosphaderm® X 34 is completely dissolved.
Phase B: Combine all ingredients of phase B.
Heat both phases separately to 70 °C and add phase B to phase A under stirring.
After stirring homogenise the formulation and adjust the pH to 5.5 ± 0.05.

Specification
Appearance: White, shiny, low viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Combine all ingredients of phase B.
Heat both phases separately to 75-80 °C.  Add phase B to A while stirring and then homogenise.
Adjust the pH to 5.5 ± 0.05.

SPECIFICATION
Appearance: White, viscous gel cream
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A.
Phase B: Disperse Cosphaderm® KG in glycerol and add it to phase A. Stir until completely dissolved.
Phase C: Add phase C and stir until everything is homogeneous.
Phase D: Prepare phase D and melt at 50 °C, then cool down to room temperature.
Add phase D to the water phase and homogenise.
Adjust pH to 5.5 ± 0.05.

Specification
Appearance: Shiny, viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients and dissolve Phase A at 40°C.
Phase B: Add phase B to phase A and adjust the pH to 5.0 – 5.5.
Phase C: Add phase C to phase A/B under soft stirring.
Phase D: Dissolve Cosphaderm® Magnolia Extract 98 in Cosphaderm® Propanediol natural and Cosphaderm® TOM. Add phase D to phase A/B/C under stirring.
Adjust the pH to 5.0 ± 0.05.

Specification
Appearance: Yellowish, translucent gel
pH: 5.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A.
Phase B: Add phase B to phase A while stirring and stir until everything is completely dissolved.
Phase C: Prepare phase C and add to phase A+B under slow stirring to prevent foaming.
Adjust pH to 5.5 ± 0.05.

Specification
Appearance: Transparent, viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A and stir until everything is dissolved.
Phase B: Add phase B to phase A under stirring.
Phase C: Combine all ingredients of phase C separately. Add then phase C to phase A and B under
stirring.
Adjust pH to 5.5 ± 0.05.

Specification
Appearance: Transparent liquid solution
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A.
Phase B: Add phase B to A carefully to avoid foaming.
Adjust the pH to 5.5 ± 0.05.

Specification
Appearance: Transparent liquid solution
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine water and Cosphagard® SA natural and raise the pH value to 10 – 11. Stir until complete dissolution. Afterwards lower the pH to approximately 6.
Phase B: Add phase B to phase A and stir until everything is completely dissolved. Heat to 70 °C.
Phase C: Combine all ingredients of phase C and heat to 70 °C.
Add phase C to A+B while stirring. Homogenise at 40°C.
Phase D: Add Cosphaderm® TOM to the emulsion.
Adjust pH to 6.0 ± 0.05.

Specification
Appearance: Light beige lotion
pH: 6.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Mix all ingredients except Cosphaderm® CHA. Add Cosphaderm® CHA and Stir phase A until complete dissolution.
Phase B: Slowly add Cosphaderm® X 34 to phase A while stirring.
Phase C: Mix phase C and add to phase A+B while carefully stirring to prevent foaming.
Adjust the pH to 5.5 ± 0.05.

Specification
Appearance: Transparent viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients and stir until Cosphaderm® X 34 is completely dissolved.
Phase B: Combine phase B and add phase B to phase A under slow stirring.
Phase C: Add phase C to phase A+B to thicken the formulation.
Adjust the pH to 5.5 ± 0.05.

Specification
Appearance: Milky, white vicous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Dissolve Phase A at 40°C.
Phase B: Combine all ingredients of phase B. Add Phase B to A under stirring.
Phase C: Add all ingredients one by one under moderate speed.
Add phase D to thicken the formulation.
Adjust the pH to 5.5 ± 0.05.

SPECIFICATION
Appearance: Slightly yellow, transparent visocus gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Add phase B to A carefully to avoid foaming.
Adjust the pH to 5.5 ± 0.05.
Phase C: Add phase C to the final formulation while stirring.

SPECIFICATION
Appearance: Transparent gel with small peeling beads
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients and stir until everything is completely dissolved.
Phase B: Dissolve the menthol in Cosphaderm® Propanediol natural add phase B to phase A under soft stirring.
Phase C: Add all ingredients of phase C and stir until everything is completely dissolved.
Phase D: Add colour if wanted.
Adjust the pH to 7.0 ± 0.05.

SPECIFICATION
Appearance: Transparent solution
pH: 7.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Prepare phase A. Raise the pH to 10 to dissolve Cosphaderm® pAS natural and stir until everything is completely dissolved. Afterwards, adjust the pH to 5.5 ± 0.05 by adding Citric Acid.
Phase B: Add all ingredients of phase B to phase A. Then heat phase A+B to 75 °C.
Phase C: Combine all ingredients and heat to 75 °C. Add then phase C to phase A+B under strong stirring and homogenise.
Phase D: Dissolve menthol in ethanol and add phase C below 40°C.
Adjust the pH to 5.5 ± 0.05.

SPECIFICATION
Appearance:  White viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A.
Phase B: Add phase B to phase A while stirring and stir until everything is completely dissolved.
Phase C: Prepare phase C and add to phase A+B under slow stirring to prevent foaming.
Adjust pH to 5.5 ± 0.05.

Specification
Appearance: Transparent, viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A. Stir until everything is completely dissolved. Afterwards, adjust the pH to 5.5 ± 0.05.
Phase B: Combine all ingredients and heat to 75-80 °C. Then add phase B to phase A while homogenising.
Add phase C to the finished formulation and homogenise.

SPECIFICATION
Appearance: White low viscous emulsion
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven