Manufacturing Process Phase A: Mix all ingredients except Cosphaderm® CHA. Add Cosphaderm® CHA and Stir phase A until complete dissolution. Phase B: Slowly add Cosphaderm® X 34 to phase A while stirring. Phase C: Mix phase C and add to phase A+B while carefully stirring to prevent foaming. Adjust the pH to 5.5 +_ 0.05. Specification Appearance: Transparent viscous gel pH: 5.5 +_ 0.05 Stability: Nhas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until dispersed. Phase B: Prepare phase B and lower the pH to ~ 5.5. Add phase C and phase A to phase B. Adjust the pH to 5.5 +_ 0.05. Heat the prepared solution to 80 - 90 °C and stir at this temperature for 2 – 3 min. Quickly pour the warm mixture into moulds and let it cool down. SPECIFICATION Appearance: Clear, solidhas not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until everything is dissolved. Phase B: Add phase B to phase A under stirring. Phase C: Combine all ingredients of phase C separately. Add then phase C to phase A and B under stirring. Adjust pH to 5.5 +_ 0.05. Specification Appearance: Transparent liquid solution pH: 5.5 +_ 0.05 Stability: No separation after centrifugationhas not

Manufacturing Process Phase A: Combine all ingredients and stir until everything is completely dissolved. Phase B: Combine phase B separately and add phase B to phase A under soft stirring. Stir until both phases are mixed. Phace C: Add phenylpropanol to phase A+B. Adjust th pH to 5.5 +_ 0.05. Specification Appearance: Transparent, viscous liquid pH: 5.5 +_ 0.05 Stability: No separation after centrifhas not

MANUFACTURING PROCESS Phase A: Dissolve Phase A at 40°C. Phase B: Combine all ingredients of phase B. Add Phase B to A under stirring. Phase C: Add all ingredients one by one under moderate speed. Add phase D to thicken the formulation. Adjust the pH to 5.5 +_ 0.05. SPECIFICATION Appearance: Slightly yellow, transparent visocus gel pH: 5.5 +_ 0.05 Stability: No separation after centrifugation (400has not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until Cosphaderm® X 34 and Cosphaderm® Sodium Hyaluronate are dispersed. Phase B: Add phase B to phase A. Phase C: Add phase C to phase A+B under stirring. Adjust the pH to 5.5 +_ 0.05. Specification Appearance: Transparent, clear gel pH: 5.5 +_ 0.05 Stability: No separation after centrifugation (4000 rpm, 30 min), stable fhas not

Manufacturing Process Phase A: Combine all ingredients and dissolve Phase A at 40°C. Adjust the pH below 7. Phase B: Add phase B to phase A under stirring and stir until everything is completely dissolved. Phase C: Prepare phase C and add to phase A+B under slow stirring to prevent foaming. Adjust the pH to 5.5 +_ 0.05. Specification Appearance: Slightly cloudy viscous gel pH: 5.5 +_ 0.05 Stabilityhas not