MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Adjust pH to 5 - 6 and add phase B. Heat to 75°C. Phase C: Combine all ingredients of phase C and heat to 75°C. Add phase C to phase A/B while stirring. Phase D: Add phase D under 40 °C and homogenise. Adjust the pH to 5.5 +_ 0.05. SPECIFICATION Appearance: White high vischas not

Manufacturing Process Phase A: Combine all ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again. Phase B: Combine Glycerin, Cosphaderm® X 34 and Cosphaderm® Sodium Hyaluronate high and stir until the powder is wetted. Then add it to phase A. Phase C: Add phase C under stirring. Adjust the pH to 4.0 +_ 0.05. Specifhas not

MANUFACTURING PROCESS Phase A: Combine the ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again. Phase B: Add phase B to A while stirring. Adjust the pH to 4.0 +_ 0.05. SPECIFICATION Appearance: Clear solution pH: 4.0 +_ 0.05 Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at has not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Combine all ingredients of phase B separately and add to phase A under stirring. Adjust pH to 5.5 +_ 0.05 if necessary. Specification Appearance: Transparent, low viscous serum pH: 5.5 +_ 0.05 Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 monthhas not

Manufacturing Process Phase A: Disperse the thickeners in glycerol and Cosphaderm® Propanediol natural. Phase B: Add demin. water and stir until everything is dissolved. Phase C: Add phase C to A/B. Adjust the pH to 5.5 +_ 0.05. Specification Appearance: Translucent, viscous gel pH: 5.5 +_ 0.05 Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperaturehas not

Manufacturing Process Phase A: Combine all ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural completely. Phase B: Add phase B and lower the pH to 4.0 +_ 0.05. Specification Appearance: Clear, liquid solution pH: 4.0 +_ 0.05 Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C Microbiological stability: provehas not

Manufacturing Process Phase A: Combine all ingredients of phase A. Phase B: Prepare phase B and slowly add to phase A under stirring. Continue stirring until everything is completely dissolved. Adjust pH to 5.5 +_ 0.05. Specification Appearance: Transparent, clear liquid pH: 5.5 +_ 0.05 Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °has not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Combine all ingredients of phase B. Heat both phases separately to 70-75 °C and add phase B to A while stirring. Then homogenise the formulation. Phase C: Dissolve Cosphaderm® Magnolia Extract 98 in Cosphaderm® Dicapo natural. Add phase C and phase D to phase A+B after cooling has not