MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until dispersed. Phase B: Prepare phase B and lower the pH to ~ 5.5. Add phase C and phase A to phase B. Adjust the pH to 5.5 +_ 0.05. Heat the prepared solution to 80 - 90 °C and stir at this temperature for 2 – 3 min. Quickly pour the warm mixture into moulds and let it cool down. SPECIFICATION Appearance: Clear, solidhas not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until Cosphaderm® X 34 and Cosphaderm® Sodium Hyaluronate are dispersed. Phase B: Add phase B to phase A. Phase C: Add phase C to phase A+B under stirring. Adjust the pH to 5.5 +_ 0.05. Specification Appearance: Light yellow gel pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no separation after centrifugation has not

Manufacturing Process Phase A: Combine all ingredients and stir until everything is completely dissolved. Phase B: Combine phase B separately and add phase B to phase A under soft stirring. Stir until both phases are mixed. Phace C: Add phenylpropanol to phase A+B. Adjust th pH to 5.5 +_ 0.05. Specification Appearance: Transparent liquid pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, nohas not

MANUFACTURING PROCESS Phase A: Dissolve Phase A at 40°C. Phase B: Combine all ingredients of phase B. Add Phase B to A under stirring. Phase C: Add all ingredients one by one under moderate speed. Add phase D to thicken the formulation. Adjust the pH to 5.5 +_ 0.05. SPECIFICATION Appearance: Slightly yellow, transparent gel pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no separationhas not