MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Combine all ingredients of phase B. Heat both phases separately to 70-75 °C and add phase B to A while homogenising. Adjust the pH to 5.5 +_ 0.05. SPECIFICATION Appearance: translucent emulsion pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no separation after has not

Manufacturing Process Phase A: Combine all ingredients of phase A. Phase B: Slowly add Cosphaderm® X 34 to phase A under stirring and stir until complete dissolution. Phase C: Prepare phase C and heat phase A+B and C separately to 80 °C. Add phase C to phase A+B and homogenise the formulation. Adjust pH to 5.5 +_ 0.05. Specification Appearance: White, shiny emulsion pH: 5.5 +_ 0.05 Stability: Michas not

Manufacturing Process Phase A: Prepare phase A and stir at 2000 rpm until complete dissolution. Phase B: Prepare phase B and heat to 50 °C until everything is melted. Let the mixture cool down to room temperature. Phase C: Prepare phase C and stir for 10 min at 800 rpm. Add phase C to phase B and stir at 2000 rpm to emulsify both phases. Add phase A to phase B+C and homogenise for 3 minutes. Adjust thhas not

Manufacturing Process This formulation can be prepared at room temperature. Phase A: Combine all ingredients. Phase B: Prepare phase B and slowly add to phase A under stirring. Continue stirring for approx. 15 min at 700 – 1000 rpm until complete dissolution. Adjust pH to 6.5 +_ 0.05 if necessary. Specification Appearance: Translucent serum pH: 6.5 +_ 0.05 Stability: Microbiological stability prohas not