FORMULATIONS

Manufacturing Process
Phase A: Combine all ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural
completely.
Phase B: Add phase B and lower the pH to 4.0 ± 0.05.

Specification
Appearance: Clear, liquid solution
pH: 4.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A.
Phase B: Disperse Cosphaderm® KG in glycerol and add it to phase A. Stir until completely dissolved.
Phase C: Add phase C and stir until everything is homogeneous.
Phase D: Prepare phase D and melt at 50 °C, then cool down to room temperature.
Add phase D to the water phase and homogenise.
Adjust pH to 5.5 ± 0.05.

Specification
Appearance: Shiny, viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Add all ingredients and to phase A and homogenise.
Adjust the pH to 5.5 ± 0.05.
Heat the mixture to its boiling point and keep this temperature for 2 – 3 minutes (Warning: Lecithins are heat sensitive. Therefore, the process of heating should be kept to a minimum!).
Quickly pour the hot mixture into a casting mould and let it cool.

Specification
Appearance: White to off-white, elastic jelly patch
pH: 5.5 ± 0.05
Stability: Stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and raise the pH to 10 to dissolve Cosphaderm® pAS natural. Stir until everything is completely dissolved. Afterwards, adjust the pH to 6.0 ±0.2 by adding Citric Acid.
Phase B: Add all ingredients of phase B to phase A and adjust the pH to 5.5 ± 0.05.
Phase C: Combine all ingredients and heat to 80 °C. Then add phase A/B to phase C while homogenising.
Add phase D to the finished formulation and homogenise.

SPECIFICATION
Appearance: White, slightly beige, high viscous cream
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine the ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again.
Phase B: Add all ingredients from phase B one after another.
Adjust the pH to 4.0 ± 0.05.

SPECIFICATION
Appearance: Transparent, low viscous solution
pH: 4.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A.
Phase B: Add phase B to phase A while stirring and stir until everything is completely dissolved.
Phase C: Prepare phase C and add to phase A+B under slow stirring to prevent foaming.
Adjust pH to 5.5 ± 0.05.

Specification
Appearance: Transparent, viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A and stir until everything is dissolved.
Phase B: Add phase B to phase A under stirring.
Phase C: Combine all ingredients of phase C separately. Add then phase C to phase A and B under
stirring.
Adjust pH to 5.5 ± 0.05.

Specification
Appearance: Transparent liquid solution
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A.
Phase B: Add phase B to A carefully to avoid foaming.
Adjust the pH to 5.5 ± 0.05.

Specification
Appearance: Transparent liquid solution
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Add Cosphaderm® X soft to the water and stir until it’s completely dissolved.
Phase B: Add phase B in small steps to phase A while stirring at 1500rpm.
Phase C: Add phase C in small steps to phase A+B while stirring at 1500rpm.
Adjust the pH to 7.0 ± 0.05.

Specification
Appearance: translucent, viscous gel
pH: 7.0 ± 0.05

Tested against bacteria according to DIN EN 1500, 1276, 1650.

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until dispersed.
Phase B: Prepare phase B and lower the pH to ~ 5.5.
Add phase C and phase A to phase B.
Adjust the pH to 5.5 ± 0.05.

Heat the prepared solution to 80 – 90 °C and stir at this temperature for 2 – 3 min.
Quickly pour the warm mixture into moulds and let it cool down.

SPECIFICATION
Appearance: Clear, solid, elastic jelly
pH: 5.5 ± 0.05
Stability: stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 5-6 again.
Phase B: Add Cosphaderm® X 34 to phase A and stir until everything is completely dissolved.
Phase C: Combine all ingredients of phase C separately. Add then phase C to phase A+B.
Phase D: Add phase D to the finished formulation.
Adjust the pH to 5.5 ± 0.05.

Specification
Appearance: Translucent gel with small peeling beads
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A under stirring and stir until Cosphaderm® X 34 is completely
dissolved.
Phase B: Combine all ingredients of phase B. Heat both phases separately to 70 °C and add phase B
to phase A under stirring.
After stirring for 5 minutes homogenise the formulation and adjust the pH to 5.5 ± 0.05.

Specification
Appearance: White, shiny emulsion
pH: 5.5 ± 0.05
Stability: Microbiological stability proven, no separation after centrifugation (4000 rpm, 30 min)

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Add Cosphaderm® X 34 while stirring and stir until everything is homogeneous.
Phase C: Combine all ingredients of phase C.
Heat both phases separately to 75 °C and add phase C to A/B while stirring. Homogenise.
Adjust the pH to 5.5 ± 0.05.

SPECIFICATION
Appearance: White, viscous lotion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A and raise the pH to 11 under stirring to dissolve cinnamic acid. Afterwards, adjust the pH to 5.5 ± 0.05 by adding Citric Acid.
Phase B: Add phase B to phase A and stir until everything is completely dissolved.
Heat phase A+B to 60 °C and add phase C under strong stirring.
Phase D: Add phase D to phase A+B below 40 °C.
Adjust the pH to 5.5 ± 0.05.

Specification
Appearance: Transparent, yellow gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A.
Phase B: Add phase B to phase A while stirring and stir until everything is completely dissolved.
Phase C: Prepare phase C and add to phase A+B under slow stirring to prevent foaming.
Adjust pH to 5.5 ± 0.05.

Specification
Appearance: Transparent, viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Adjust the pH to 5.5 ± 0.05.
Phase B: Combine all ingredients of phase B.
Heat phase B to 80 °C and slowly add phase A to B while homogenising.

SPECIFICATION
Appearance:  white emulsion
pH: 5.5 ± 0.05
Stability: Microbiological stability proven, no separation after centrifugation (4000 rpm, 30 min)