FORMULATIONS

Manufacturing Process
Phase A: Combine all ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again.
Phase B: Combine Glycerin, Cosphaderm® X 34 and Cosphaderm® Sodium Hyaluronate high and stir until the powder is wetted. Then add it to phase A.
Phase C: Add phase C under stirring.
Adjust the pH to 4.0 ± 0.05.

Specification
Appearance: Transparent, semi-viscous gel
pH: 4.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Combine all ingredients of phase B.
Heat both phases separately to 70-75 °C and add phase B to A while stirring.
Then homogenise the formulation.
Phase C: Dissolve Cosphaderm® Magnolia Extract 98 in Cosphaderm® Dicapo natural.
Add phase C and phase D to phase A+B after cooling to 40 °C while stirring.
Adjust the pH to 5.5 ± 0.05.

SPECIFICATION
Appearance: Light beige, shiny, fluid emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 75 °C.
Phase B: Combine all ingredients and heat to 75 °C. Add then phase B to phase A under strong stirring and homogenise.
Phase C: Add phase C to the formulation and stir.
Adjust the pH to 5.5 ± 0.05.

SPECIFICATION
Appearance: White, fluid emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Add phase B to A while stirring.
Phase C: Add phase C to the water phase while stirring. Then heat the water phase to 70-75 °C.
Phase D: Combine all ingredients of phase D and heat to 75°C. Phase E is added to the oil phase just before emulsion is formed.
Add phase D+E to the water phase while homogenising.
Adjust the pH to 5.5 ± 0.05.

SPECIFICATION
Appearance: Light beige, high viscous cream
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Prepare phase A and stir until everything is completely dissolved. Adjust pH value to 5.5.
Phase B: Add Cosphaderm® Sodium pAS natural to phase A under stirring.
Phase C: Prepare phase C and add it to phase A/B. Homogenise.
Adjust pH value to 5.5 ± 0.05.

Specification
Appearance: Beige, shiny, low viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Prepare phase A. Raise the pH to 10 to dissolve Cosphaderm® pAS natural and stir until everything is completely dissolved. Afterwards, adjust the pH to 5.5 ± 0.05 by adding Citric Acid.
Phase B: Prepare phase B and add it to phase A while stirring. Stir until everything is completely dissolved.
Phase C: Prepare phase C and add it to phase A/B. Homogenise.
Adjust pH value to 5.5 ± 0.05.

Specification
Appearance: Beige, shiny, low viscous emulsion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 70-75 °C.
Phase B: Combine all ingredients of phase B and heat to 75°C. Phase C is added to the oil phase just before emulsion is formed.
Add phase B+C to the water phase while stirring. Homogenise at 40°C.
Adjust the pH to 5.5 ± 0.05.

SPECIFICATION
Appearance: White, viscous cream
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A and stir slowly until everything is completely dissolved.
Phase B: Combine all ingredients of phase B.
Add phase B to phase A under stirring with the propeller stirrer.
Adjust the pH to 5.5 ± 0.05.

Specification
Appearance: Milky, white viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A.
Phase B: Add phase B to phase A while stirring and stir until everything is completely dissolved.
Phase C: Prepare phase C and add to phase A+B under slow stirring to prevent foaming.
Adjust pH to 5.5 ± 0.05.

Specification
Appearance: Transparent, viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine water and Cosphagard® SA natural and raise the pH value to 10 – 11. Stir until complete dissolution. Afterwards lower the pH to approximately 6.
Phase B: Add phase B to phase A and stir until everything is completely dissolved. Heat to 70 °C.
Phase C: Combine all ingredients of phase C and heat to 70 °C.
Add phase C to A+B while stirring. Homogenise at 40°C.
Phase D: Add Cosphaderm® TOM to the emulsion.
Adjust pH to 6.0 ± 0.05.

Specification
Appearance: Light beige lotion
pH: 6.0 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Add Cosphaderm® X soft to the water and stir until it’s completely dissolved.
Phase B: Add phase B in small steps to phase A while stirring at 1500rpm.
Phase C: Add phase C in small steps to phase A+B while stirring at 1500rpm.
Adjust the pH to 7.0 ± 0.05.

Specification
Appearance: translucent, viscous gel
pH: 7.0 ± 0.05

Tested against bacteria according to DIN EN 1500, 1276, 1650.

MANUFACTURING PROCESS
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 70-75 °C.
Phase B: Combine all ingredients and heat to 75 °C. Add then phase B to phase A under strong stirring and homogenise.
Phase C: Dissolve the menthol in Cosphaderm® Hexiol natural and add below 40°C.
Adjust the pH to 5.5 ± 0.05.

SPECIFICATION
Appearance: White viscous lotion
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven

Manufacturing Process
Phase A: Combine all ingredients of phase A.
Phase B: Add phase B to phase A while stirring and stir until everything is completely dissolved.
Phase C: Prepare phase C and add to phase A+B under slow stirring to prevent foaming.
Adjust pH to 5.5 ± 0.05.

Specification
Appearance: Transparent, viscous gel
pH: 5.5 ± 0.05
Stability: No separation after centrifugation (4000 rpm, 30 min), stable for 3 months at room temperature and 40 °C
Microbiological stability: proven