FORMULATIONS

Manufacturing Process
Combine all ingredients of phase A and stir with a propeller stirrer at 1500 – 2000 rpm until everything is
completely dissolved. Then add phase B to phase A under stirring.
Adjust the pH to 6.0 ± 0.05 to thicken the formulation.

Specification
Appearance: Transparent, clear gel
pH: 6.0 ± 0.05
Stability: Microbiological stability proven, no separation after centrifugation (4000 rpm, 30 min)

MANUFACTURING PROCESS
This formulation can be prepared at room temperature.
Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved.
Phase B: Add phase B to phase A.
Phase C: Add Phase C and stir until everything is completely dissolved.
Adjust pH to 6.5 ± 0.05 if necessary.

SPECIFICATION
Appearance: Transparent serum
pH: 6.5 ± 0.05
Stability: Microbiological stability proven, no separation after centrifugation (4000 rpm, 30 min)

Manufacturing Process
Phase A: Prepare phase A and stir at 2000 rpm until complete dissolution.
Phase B: Prepare phase B and heat to 50 °C until everything is melted. Let the mixture cool down to
room temperature.
Phase C: Prepare phase C and stir for 10 min at 800 rpm.
Add phase C to phase B and stir at 2000 rpm to emulsify both phases.
Add phase A to phase B+C and homogenise for 3 minutes.
Adjust the pH to 5.5 ± 0.05.

Specification
Appearance: White, shiny emulsion
pH: 5.5 ± 0.05
Stability: Microbiological stability proven, no separation after centrifugation (4000 rpm, 30 min)

Manufacturing Process
Phase A: Prepare phase A. Raise the pH to 10 to dissolve Cosphaderm® AS and stir until everything is completely dissolved.
Afterwards, adjust the pH to 5.5 ± 0.05 by adding Citric Acid.
Phase B: Prepare phase B and homogenise for 5 minutes with high performance disperser (stator/rotor) at max. speed.
Add phase B to phase A in small steps under stirring.
Adjust pH value to 5.5 ± 0.05.

Specification
Appearance: Shiny emulsion
pH: 5.5 ± 0.05
Stability: Microbiological stability proven, no separation after centrifugation (4000 rpm, 30 min)

Manufacturing Process
Phase A: Prepare phase A and stir until dispersed.
Phase B: Slowly add the water to phase A under stirring and stir until complete dissolution.
Phase C: Prepare phase C and stir for 10 minutes. Add phase C to phase A+B and adjust pH
to 5.5 – 6.0 ± 0.05.
Phase D: Add colour if wanted.
Heat the mixture to its boiling point and keep this temperature for 2 – 3 minutes.
Quickly pour the hot mixture into a casting mould and let it cool.

Specification
Appearance: Translucent or coloured, elastic gel
pH: 5.5 – 6.0 ± 0.05
Stability: Microbiological stability proven, no separation after centrifugation (4000 rpm, 30 min)

MANUFACTURING PROCESS
Phase A: Prepare phase A and stir until dispersed. Adjust the pH to 6.5 ± 0.05.
Phase B: Add colour if wanted.
Heat the mixture to 80-90°C and keep this temperature for 2 – 3 minutes.
Quickly pour the hot mixture into a casting mould and let it cool.

SPECIFICATION
Appearance: Translucent or coloured, elastic gel
pH: 6.5 ± 0.05
Stability: Microbiological stability proven, no separation after centrifugation (4000 rpm, 30 min)

Manufacturing Process
Phase A: Combine all ingredients of phase A and stir until complete dissolution.
Adjust the pH value to 5.5 ± 0.05.
Phase B: Prepare phase B in a separate beaker.
Add phase B to phase A without stirring and pour mixture into spray flask.

Specification
Appearance: Two-phase system with oil phase on top of translucent water phase
pH: 5.5 ± 0.05
Stability: Microbiological stability proven

Manufacturing Process
Phase A: Combine all ingredients of phase A and heat to 80 °C.
Phase B: Combine all of the liquid ingredients and add the powders while stirring.
Then heat to 80 °C.
Afterwards combine phase A and B and homogenise the mixture.
Phase C: Add phase C to the formulation (<40 °C) and stir.
Homogenise a second time if needed.
Adjust pH to 5.5 ± 0.05.

Specification
Appearance: White, shiny emulsion
pH: 5.5 ± 0.05
Stability: Microbiological stability proven, no separation after centrifugation (4000 rpm, 30 min)