MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Heat to 70-75 °C. Phase B: Combine all ingredients of phase B and heat to 75°C. Phase C is added to the oil phase just before emulsion is formed. Add phase B+C to the water phase while stirring. Homogenise at 40°C. Adjust the pH to 5.5 ± 0.05. SPECIFICATION Appearance: White cream has not

MANUFACTURING PROCESS Phase A: Combine the ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again. Phase B: Add all ingredients from phase B one after another. Adjust the pH to 4.0 ± 0.05. SPECIFICATION Appearance: Clear solution pH: 4.0 ± 0.05 Stability: Microbiological stability proven, no separation after centrhas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until dispersed. Phase B: Prepare phase B and lower the pH to ~ 5.5. Add phase C and phase A to phase B. Adjust the pH to 5.5 +_ 0.05. Heat the prepared solution to 80 - 90 °C and stir at this temperature for 2 – 3 min. Quickly pour the warm mixture into moulds and let it cool down. SPECIFICATION Appearance: Clear, solidhas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Add phase B to A carefully to avoid foaming. Adjust the pH to 5.5 ± 0.05. Phase C: Add phase C to the final formulation while stirring. SPECIFICATION Appearance: Transparent gel with small peeling beads pH: 5.5 ± 0.05 Stability: Microbiological stability proven, no separatihas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Slowly add phase B to A while stirring. Phase C: Mix all ingredients of phase C and add to phase A+B while stirring. Adjust the pH to 5.0 +_ 0.05. SPECIFICATION Appearance: Clear solution pH: 5.0 +_ 0.05 Stability: Microbiological stability proven, no separation after centrifhas not

MANUFACTURING PROCESS Phase A: Combine the ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again. Phase B: Add phase B to A while stirring. Adjust the pH to 4.0 +_ 0.05. SPECIFICATION Appearance: Clear solution pH: 4.0 +_ 0.05 Stability: Microbiological stability proven, no separation after centrifugation (4000 rpmhas not

MANUFACTURING PROCESS Phase A: Prepare phase A and stir until dispersed. Adjust the pH to 6.5 +_ 0.05. Phase B: Add colour if wanted. Heat the mixture to 80-90°C and keep this temperature for 2 – 3 minutes. Quickly pour the hot mixture into a casting mould and let it cool. SPECIFICATION Appearance: Translucent or coloured, elastic gel pH: 6.5 +_ 0.05 Stability: Microbiological stability proven, nhas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Add Cosphaderm® SF-75H to phase A and let it soak for 20 minutes. Then heat phase A+B to 70 °C. Phase C: Combine all ingredients of phase C and heat to 70 °C. Add then phase C to phase A+B under strong stirring and homogenise the formulation. Adjust the pH to 4.8 +_ 0.05. SPhas not