MANUFACTURING PROCESS Phase A: Combine the ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again. Phase B: Add all ingredients from phase B one after another. Adjust the pH to 4.0 ± 0.05. SPECIFICATION Appearance: Clear solution pH: 4.0 ± 0.05 Stability: Microbiological stability proven, no separation after centrhas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Adjust the pH to 5.5 ± 0.05. Phase B: Combine all ingredients of phase B. Heat phase B to 80 °C and slowly add phase A to B while homogenising. SPECIFICATION Appearance:  white emulsion pH: 5.5 ± 0.05 Stability: Microbiological stability proven, no separation after centrifugation has not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Add phase B to A carefully to avoid foaming. Adjust the pH to 5.5 ± 0.05. Phase C: Add phase C to the final formulation while stirring. SPECIFICATION Appearance: Transparent gel with small peeling beads pH: 5.5 ± 0.05 Stability: Microbiological stability proven, no separatihas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Slowly add phase B to A while stirring. Phase C: Mix all ingredients of phase C and add to phase A+B while stirring. Adjust the pH to 5.0 +_ 0.05. SPECIFICATION Appearance: Clear solution pH: 5.0 +_ 0.05 Stability: Microbiological stability proven, no separation after centrifhas not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until everything is dissolved. Phase B: Add phase B to phase A under stirring. Phase C: Combine all ingredients of phase C separately. Add then phase C to phase A and B under stirring. Adjust pH to 5.5 +_ 0.05. Specification Appearance: Transparent solution pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no sepahas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Combine all ingredients of phase B. Heat both phases separately to 70-75 °C and add phase B to A while homogenising. Adjust the pH to 5.5 +_ 0.05. SPECIFICATION Appearance: translucent emulsion pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no separation after has not

Manufacturing Process Phase A: Combine all ingredients of phase A and heat to 80 °C. Phase B: Combine all of the liquid ingredients and add the powders while stirring. Then heat to 80 °C. Afterwards combine phase A and B and homogenise the mixture. Phase C: Add phase C to the formulation (<40 °C) and stir. Homogenise a second time if needed. Adjust pH to 5.5 +_ 0.05. Specification Appearance:has not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until everything is dissolved. Phase B: Combine all ingredients and heat phase B to 40 – 50 °C. Afterwards combine phase A and B while stirring slowly until a homogeneous gel is formed. Phase C: Add panthenol to the mixture (<40 °C). Adjust pH to 5.5 +_ 0.05. Specification Appearance: Yellowish, slightly turbid, viscoushas not