MANUFACTURING PROCESS Phase A: Combine the ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again. Phase B: Add all ingredients from phase B one after another. Adjust the pH to 4.0 ± 0.05. SPECIFICATION Appearance: Clear solution pH: 4.0 ± 0.05 Stability: Microbiological stability proven, no separation after centrhas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Adjust the pH to 5.5 ± 0.05. Phase B: Combine all ingredients of phase B. Heat phase B to 80 °C and slowly add phase A to B while homogenising. SPECIFICATION Appearance:  white emulsion pH: 5.5 ± 0.05 Stability: Microbiological stability proven, no separation after centrifugation has not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until dispersed. Phase B: Prepare phase B and lower the pH to ~ 5.5. Add phase C and phase A to phase B. Adjust the pH to 5.5 +_ 0.05. Heat the prepared solution to 80 - 90 °C and stir at this temperature for 2 – 3 min. Quickly pour the warm mixture into moulds and let it cool down. SPECIFICATION Appearance: Clear, solidhas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Slowly add phase B to A while stirring. Phase C: Mix all ingredients of phase C and add to phase A+B while stirring. Adjust the pH to 5.0 +_ 0.05. SPECIFICATION Appearance: Clear solution pH: 5.0 +_ 0.05 Stability: Microbiological stability proven, no separation after centrifhas not

MANUFACTURING PROCESS Phase A: Prepare phase A and stir until dispersed. Adjust the pH to 6.5 +_ 0.05. Phase B: Add colour if wanted. Heat the mixture to 80-90°C and keep this temperature for 2 – 3 minutes. Quickly pour the hot mixture into a casting mould and let it cool. SPECIFICATION Appearance: Translucent or coloured, elastic gel pH: 6.5 +_ 0.05 Stability: Microbiological stability proven, nhas not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until everything is dissolved. Phase B: Add phase B to phase A under stirring. Phase C: Combine all ingredients of phase C separately. Add then phase C to phase A and B under stirring. Adjust pH to 5.5 +_ 0.05. Specification Appearance: Transparent solution pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no sepahas not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Combine all ingredients of phase B. Heat both phases separately to 70-75 °C and add phase B to A very slowly while homogenising. Phase C: Cool down to 40°C and add Phase C. Specification Appearance: Slightly yellowish gel Stability: Microbiological stability proven (Water ahas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Combine all ingredients of phase B. Heat both phases separately to 75 °C and add phase B to A while homogenising. Adjust the pH to 5.5 +_ 0.05. SPECIFICATION Appearance:  white emulsion pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no separation after centrifhas not