MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until dispersed. Phase B: Prepare phase B and lower the pH to ~ 5.5. Add phase C and phase A to phase B. Adjust the pH to 5.5 +_ 0.05. Heat the prepared solution to 80 - 90 °C and stir at this temperature for 2 – 3 min. Quickly pour the warm mixture into moulds and let it cool down. SPECIFICATION Appearance: Clear, solidhas not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until everything is dissolved. Phase B: Add phase B to phase A under stirring. Phase C: Combine all ingredients of phase C separately. Add then phase C to phase A and B under stirring. Adjust pH to 5.5 +_ 0.05. Specification Appearance: Transparent solution pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no sepahas not

MANUFACTURING PROCESS Phase A: Dissolve Phase A at 40°C. Phase B: Combine all ingredients of phase B. Add Phase B to A under stirring. Phase C: Add all ingredients one by one under moderate speed. Add phase D to thicken the formulation. Adjust the pH to 5.5 +_ 0.05. SPECIFICATION Appearance: Slightly yellow, transparent gel pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no separationhas not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until everything is dissolved. Phase B: Combine all ingredients and heat phase B to 40 – 50 °C. Afterwards combine phase A and B while stirring slowly until a homogeneous gel is formed. Phase C: Add panthenol to the mixture (<40 °C). Adjust pH to 5.5 +_ 0.05. Specification Appearance: Yellowish, slightly turbid, viscoushas not

Manufacturing Process Phase A: Combine all ingredients of phase A. Phase B: Slowly add phase B to phase A under stirring. Stir until complete dissolution. Phase C: Prepare phase C and add to phase A+B under slow stirring to prevent foaming. Adjust pH to 5.5 +_ 0.05. Specification Appearance: Transparent gel pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no separation after centrifugatihas not

Manufacturing Process Phase A+B: Combine phase A in a beaker and stir until Cosphaderm® X 34 is dissolved. Heat phase A to 60 °C and add phase B under strong stirring. Phase C: Add phase C to phase A+B below 40 °C. Phase D: Before adding phase D to the mixture increase the pH to 11 and add Cosphaderm® CA natural. Afterwards lower the pH to 5.5 +_ 0.05. Specification Appearance: Transparent, yellhas not

Manufacturing Process This formulation can be prepared at room temperature. Phase A: Combine all ingredients and stir until everything is completely dissolved. Phase B: Combine phase B separately and add phase B to phase A under soft stirring. Stir until both phases are mixed. Phace C: Add Cosphaderm® PhP to phase A+B. Adjust th pH to 5.5 +_ 0.05. Specification Appearance: Transparent liquid pH: 5.has not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until Cosphaderm® X 34 and Cosphaderm® Sodium Hyaluronate are dispersed. Phase B: Add phase B to phase A. Phase C: Add phase C to phase A+B under stirring. Adjust the pH to 5.5 +_ 0.05. Specification Appearance: Light yellow gel pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no separation after centrifugation has not