MANUFACTURING PROCESS Phase A: Combine the ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again. Phase B: Add all ingredients from phase B one after another. Adjust the pH to 4.0 ± 0.05. SPECIFICATION Appearance: Clear solution pH: 4.0 ± 0.05 Stability: Microbiological stability proven, no separation after centrhas not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until everything is dissolved. Phase B: Combine all ingredients and heat phase B to 40 – 50 °C. Afterwards combine phase A and B while stirring slowly until a homogeneous gel is formed. Phase C: Add panthenol to the mixture (<40 °C). Adjust pH to 5.5 +_ 0.05. Specification Appearance: Yellowish, slightly turbid, viscoushas not