MANUFACTURING PROCESS Phase A: Combine the ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again. Phase B: Add all ingredients from phase B one after another. Adjust the pH to 4.0 ± 0.05. SPECIFICATION Appearance: Clear solution pH: 4.0 ± 0.05 Stability: Microbiological stability proven, no separation after centrhas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Add phase B to A while stirring. Then heat phase A+B to 75 °C. Phase C: Combine all ingredients of phase C and heat to 75 °C. Then add phase C to phase A+B under strong stirring and homogenise the formulation. Adjust the pH to 4.5 +_ 0.05. SPECIFICATION Appearance: White crehas not

MANUFACTURING PROCESS Phase A: Combine the ingredients of phase A. Raise the pH to 11 to dissolve Cosphagard® SA natural. When everything is dissolved, lower the pH back to 4-5 again. Phase B: Add phase B to A while stirring. Adjust the pH to 4.0 +_ 0.05. SPECIFICATION Appearance: Clear solution pH: 4.0 +_ 0.05 Stability: Microbiological stability proven, no separation after centrifugation (4000 rpmhas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Add phase B to A while stirring. Phase C: Add phase C to the water phase while stirring. Then heat the water phase to 70-75 °C. Phase D: Combine all ingredients of phase D and heat to 75°C. Phase E is added to the oil phase just before emulsion is formed. Add phase D+E to the wahas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Add Cosphaderm® SF-75H to phase A and let it soak for 20 minutes. Then heat phase A+B to 70 °C. Phase C: Combine all ingredients of phase C and heat to 70 °C. Add then phase C to phase A+B under strong stirring and homogenise the formulation. Adjust the pH to 4.8 +_ 0.05. SPhas not