MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until dispersed. Phase B: Prepare phase B and lower the pH to ~ 5.5. Add phase C and phase A to phase B. Adjust the pH to 5.5 +_ 0.05. Heat the prepared solution to 80 - 90 °C and stir at this temperature for 2 – 3 min. Quickly pour the warm mixture into moulds and let it cool down. SPECIFICATION Appearance: Clear, solidhas not

MANUFACTURING PROCESS Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Add phase B to A carefully to avoid foaming. Adjust the pH to 5.5 ± 0.05. Phase C: Add phase C to the final formulation while stirring. SPECIFICATION Appearance: Transparent gel with small peeling beads pH: 5.5 ± 0.05 Stability: Microbiological stability proven, no separatihas not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until everything is dissolved. Phase B: Add phase B to phase A under stirring. Phase C: Combine all ingredients of phase C separately. Add then phase C to phase A and B under stirring. Adjust pH to 5.5 +_ 0.05. Specification Appearance: Transparent solution pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no sepahas not

Manufacturing Process Phase A: Combine all ingredients of phase A and stir until everything is completely dissolved. Phase B: Combine all ingredients of phase B. Heat both phases separately to 70-75 °C and add phase B to A very slowly while homogenising. Phase C: Cool down to 40°C and add Phase C. Specification Appearance: Slightly yellowish gel Stability: Microbiological stability proven (Water ahas not

MANUFACTURING PROCESS Phase A: Combine all ingredients and stir until everything is completely dissolved. Phase B: Dissolve the menthol in Cosphaderm® Propanediol natural add phase B to phase A under soft stirring. Phase C: Add all ingredients of phase C and stir until everything is completely dissolved. Adjust the pH to 7.0 +_ 0.05. SPECIFICATION Appearance: transparent liquid pH: 7.0 +_ 0.05 Stabhas not

MANUFACTURING PROCESS Phase A: Dissolve Phase A at 40°C. Phase B: Combine all ingredients of phase B. Add Phase B to A under stirring. Phase C: Add all ingredients one by one under moderate speed. Add phase D to thicken the formulation. Adjust the pH to 5.5 +_ 0.05. SPECIFICATION Appearance: Slightly yellow, transparent gel pH: 5.5 +_ 0.05 Stability: Microbiological stability proven, no separationhas not

Manufacturing Process Phase A: Combine all ingredients of phase A. Phase B: Melt all ingredients of phase B (35-40°C) and add to phase A. Mix until everything is homogeneous. Press mixture into molds. Specification Appearance: Solid, white bar Stability: Microbiological stability proven (Water activity value less than 0.75)has not

Manufacturing Process Phase A: Add Cosphaderm® X soft to the water and stir until it’s completely dissolved. Phase B: Add phase B in small steps to phase A while stirring at 1500rpm. Phase C: Add phase C in small steps to phase A+B while stirring at 1500rpm. Adjust the pH to 7.0 +_ 0.05. Specification Appearance: translucent, viscous gel pH: 7.0 +_ 0.05 Tested against bacteria according to DIN has not